期刊
APPLIED OPTICS
卷 57, 期 18, 页码 D117-D122出版社
OPTICAL SOC AMER
DOI: 10.1364/AO.57.00D117
关键词
-
类别
资金
- Javna Agencija za Raziskovalno Dejavnost RS (ARRS) [BI-US 16-17-059, P1-0192, PR-07590]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [P41EB015890]
We are combining two optical techniques, pulsed photothermal radiometry (PPTR) and diffuse reflectance spectroscopy (DRS), for noninvasive assessment of the structure and composition of human skin in vivo. The analysis involves simultaneous multidimensional fitting of the measured PPTR signals and DRS spectra with predictions of a numerical model of light transport (Monte Carlo) in a four-layer model optical model of human skin, accounting for the epidermis, papillary and reticular dermis, and subcutis. The assessed epidermal thickness values were tested by coregistration with a multiphoton microscope, which provides vertical sectioning capability based on two-photon excited fluorescence and second-harmonic generation in selected skin components. The comparison shows that these values correspond well to the maximal epidermal thicknesses measured in the multiphoton microscopy images, the rete ridges. (C) 2018 Optical Society of America
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据