期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 102, 期 5, 页码 2063-2073出版社
SPRINGER
DOI: 10.1007/s00253-018-8787-x
关键词
Coumarin; Quorum sensing inhibition; Antibiofilm; Anti-infectives; Natural products
资金
- European Commission [607786, CP-TP-312184, 311975, 287589, 256596]
- Science Foundation Ireland [SSPC-2, 12/RC/2275, 13/TIDA/B2625, 12/TIDA/B2411, 12/TIDA/B2405, 14/TIDA/2438, 15/TIDA/2977]
- Department of Agriculture and Food (FIRM/RSF/CoFoRD) [FIRM 08/RDC/629, FIRM 1/F009/MabS, FIRM 13/F/516]
- Irish Research Council for Science, Engineering and Technology [PD/2011/2414, GOIPG/2014/647]
- Health Research Board/Irish Thoracic Society [MRCG-2014-6]
- Marine Institute [C2CRA 2007/082]
- Teagasc
- Enterprise Ireland [CF-2017-0757-P]
- Science Foundation Ireland (SFI) [12/TIDA/B2411, 13/TIDA/B2625, 14/TIDA/2438, 15/TIDA/2977] Funding Source: Science Foundation Ireland (SFI)
Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinical effectiveness of conventional antibiotics. An intricate cell-cell communication system termed quorum sensing (QS) and the coordinated multicellular behaviour of biofilm formation have both been identified as promising targets for the treatment and clinical management of microbial infections. QS systems allow bacteria to adapt rapidly to harsh conditions, and are known to promote the formation of antibiotic tolerant biofilm communities. It is well known that biofilm is a recalcitrant mode of growth and it also increases bacterial resistance to conventional antibiotics. The pharmacological properties of coumarins have been well described, and these have included several that possess antimicrobial properties. More recently, reports have highlighted the potential role of coumarins as alternative therapeutic strategies based on their ability to block the QS signalling systems and to inhibit the formation of biofilms in clinically relevant pathogens. In addition to human infections, coumarins have also been found to be effective in controlling plant pathogens, infections in aquaculture, food spoilage and in reducing biofouling caused by eukaryotic organisms. Thus, the coumarin class of small molecule natural product are emerging as a promising strategy to combat bacterial infections in the new era of antimicrobial resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据