期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 102, 期 11, 页码 4629-4640出版社
SPRINGER
DOI: 10.1007/s00253-018-8927-3
关键词
CRISPR; Cas9; Genetic modification; Protozoa; Apicomplexa; Genome editing
资金
- National Center for Science, Poland PRELUDIUM [2012/07/N/NZ9/02060]
- Ministry of Science and Higher Education in Poland [428/STYP/11/2016]
- National Center for Science, Poland HARMONIA [2016/22/M/NZ2/00548]
The CRISPR/Cas9 system, a natural defence system of bacterial organisms, has recently been used to modify genomes of the most important protozoa parasites. Successful genome manipulations with the CRISPR/Cas9 system are changing the present view of genetics in parasitology. The application of this system offers a major chance to overcome the current restriction in culturing, maintaining and analysing protozoan parasites, and allows dynamic analysis of parasite genes functions, leading to a better understanding of pathogenesis. CRISPR/Cas9 system will have a significant influence on the process of developing novel drugs and treatment strategies against protozoa parasites.
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