期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 102, 期 11, 页码 4717-4727出版社
SPRINGER
DOI: 10.1007/s00253-018-8945-1
关键词
Biocatalysis; Debaryomyces; Green chemistry; Phenylacetylcarbinol; Seawater
资金
- Universitat de Valencia [UV-INV-AE15-323062]
Acyloin condensation between benzaldehyde and decarboxylated pyruvate results in the production of R-(-)-phenylacetylcarbinol, a chiral precursor of the drug ephedrine. Huge research efforts have been made to improve the conditions of this reaction and to avoid the generation of by-products. Recently, we reported the advantages of using whole cells of the yeast Debaryomyces etchellsii as biocatalysts for this purpose. In this work, a new strategy, which fulfills green chemistry principles, is proposed and is based on using seawater as a gentle solvent. We demonstrate that, under these conditions, several improvements can be made compared to employing freshwater: (1) the conversion of the starting material in (R)-PAC is higher and with a minimum production of by-products; (2) it is possible to increase at least twofold the benzaldehyde load in the reaction medium; (3) cells can maintain their activity after several recycling rounds, which makes (R)-PAC production an easy and economical process.
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