期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 102, 期 8, 页码 3439-3451出版社
SPRINGER
DOI: 10.1007/s00253-018-8803-1
关键词
Genome-scale modeling; Systematic metabolic engineering; Cell growth; Microbial biosynthesis
资金
- National Program for Support of Top-notch Young Professionals
- National Natural Science Foundation of China [21422602]
- Postdoctoral Science Foundation of Jiang Su [1701140C]
The primary aims and challenges associated with microbial fermentation include achieving faster cell growth, higher productivity, and more robust production processes. Genome-scale biological models, predicting the formation of an interaction among genetic materials, enzymes, and metabolites, constitute a systematic and comprehensive platform to analyze and optimize the microbial growth and production of biological products. Genome-scale biological models can help optimize microbial growth-associated traits by simulating biomass formation, predicting growth rates, and identifying the requirements for cell growth. With regard to microbial product biosynthesis, genome-scale biological models can be used to design product biosynthetic pathways, accelerate production efficiency, and reduce metabolic side effects, leading to improved production performance. The present review discusses the development of microbial genome-scale biological models since their emergence and emphasizes their pertinent application in improving industrial microbial fermentation of biological products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据