Synthesis, Characterization of Novel Furan Based Imidazolones and Their Boilogical Studies

Background: Heterocyclic derivatives are of various pharmacological activities. The five membered rings, imidazole moiety is present in wide range of naturally occurring molecules, for example furan is a five membered heterocyclic nucleus which contain oxygen atom as heteroatom having broad spectrum of antimicrobial activities against microbes and fungal strains. Results: We prepared a series of 3-(4-Acetyl-phenyl)-5-arylidene-2-furan-2-yl-3, 5-dihydroimidazol-4-one with different aldehydes through Erlenmeyer reaction and condensation methods. The newly synthesized compounds were characterized by IR, (HNMR)-H-1, C-13 NMR and mass spectral studies. All final compounds are screened for their antimicrobial activities done by Gram-negative bacteria Proteus, Gram-positive bacteria Bacillus subtili and one yeast type fungi, C. albicans. Anti oxidant assay through DPPH radical scavenging, Nitric oxide assay. Conclusion: Furan based compounds having greater importance in medicinal chemistry. This research work is an attempt to highlight some compounds shows good potency against microbial activity. Of all the compounds 3d appear to be a potent molecule. 3a, 3c killed all micro organism and there by showing their non-specificity in recognising the micro organism. 3e appears to be less potent molecule as, it is not acting on Gram-negative bacteria's and B. subtilis (Gram-positive) bacteria and it's killing Micrococcus with MIC of 92 mu g. Among all 3f compound shows good potent against DPPH and nitric oxide radical scavenging assay.