期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms17060806
关键词
cell-penetrating peptide (CPPs); transferrin; blood brain barrier (BBB); liposomes; functionalization
资金
- National Institute of General Medical Sciences (NIGMS) of the National Institute of Health [R15 GM114701]
- Fraternal Order of Eagles
The challenge of effectively delivering therapeutic agents to brain has led to an entire field of active research devoted to overcome the blood brain barrier (BBB) and efficiently deliver drugs to brain. This review focusses on exploring the facets of a novel platform designed for the delivery of drugs to brain. The platform was constructed based on the hypothesis that a combination of receptor-targeting agent, like transferrin protein, and a cell-penetrating peptide (CPP) will enhance the delivery of associated therapeutic cargo across the BBB. The combination of these two agents in a delivery vehicle has shown significantly improved (p < 0.05) translocation of small molecules and genes into brain as compared to the vehicle with only receptor-targeting agents. The comprehensive details of the uptake mechanisms and properties of various CPPs are illustrated here. The application of this technology, in conjunction with nanotechnology, can potentially open new horizons for the treatment of central nervous system disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据