期刊
JOURNAL OF BREATH RESEARCH
卷 10, 期 2, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1752-7155/10/2/021002
关键词
cystic fibrosis; SIFT-MS; acetic acid
资金
- Czech Science Foundation GACR project [14-14534S]
A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) is significantly elevated in the exhaled breath of CF patients, independent of the Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative median 182 ppbv), compared to that of healthy controls (median 48 ppbv). The cause for this may be decreased pH of the mucus lining the CF airways. Thus, we speculate that non-invasive measurement of breath acetic acid concentration could serve as an indicator of the acidity of the CF airways mucosa.
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