4.7 Article

Urinary Excretion of Sulfur Metabolites and Risk of Cardiovascular Events and All-Cause Mortality in the General Population

期刊

ANTIOXIDANTS & REDOX SIGNALING
卷 30, 期 17, 页码 1999-2010

出版社

MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2017.7040

关键词

epidemiology; cardiovascular events; mortality; sulfate; thiosulfate; hydrogen sulfide

资金

  1. Dutch Kidney Foundation
  2. J.K. de Cock Foundation [2015-07]
  3. Groningen University Institute for Drug Exploration (GUIDE)
  4. Dutch Kidney foundation [P13-114]
  5. Top Institute Food and Nutrition [CH-001, CH-003]
  6. National Institute for Health Research through the NIHR Southampton Biomedical Research Centre

向作者/读者索取更多资源

Aims: Thiosulfate and sulfate are metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular (CV) protective properties. Urinary thiosulfate excretion and sulfate excretion are associated with favorable disease outcome in high-risk patient groups. We investigated the relationship between urinary excretion of sulfur metabolites, and risk of CV events and all-cause mortality in the general population. Results: Subjects (n = 6839) of the Prevention of Renal and Vascular End-stage Disease (PREVEND) study were followed prospectively. At baseline, 24-h urinary excretion of thiosulfate and sulfate was determined. Median urinary thiosulfate and sulfate excretion values were 1.27 (interquartile range [IQR] 0.89-2.37) mol/24h and 15.7 (IQR 12.0-20.3) mmol/24h, respectively. Neither thiosulfate nor sulfate excretion showed an independent association with risk of CV events. Sulfate, but not thiosulfate, was inversely associated with risk of all-cause mortality, independent of potential confounders (hazard ratio 0.73 [95% confidence interval 0.63-0.84], p<0.001). This association appeared most pronounced for normolipidemic subjects (p(interaction)=0.019). Innovation: The strong association between sulfate excretion and mortality in the general population emphasizes the (patho)physiological importance of sulfate or its precursor H2S. Conclusion: We hypothesize that urinary sulfate excretion, which is inversely associated with all-cause mortality in the general population, holds clinical relevance as a beneficial modulator in health and disease.

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