期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 28, 期 9, 页码 773-796出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2017.7175
关键词
environmental chemicals; air pollution; heavy metals; pesticides; noise exposure; deafness; hearing loss; mental stress; neuropsychiatric disorders
资金
- Ministerio de Economia, Industria y Competitividad (MINECO) from Spain [SAF 2015-66107-R]
- Consolredox Network from Spain [SAF 2015-71521-REDC]
- Instituto de Salud Carlos III network REDinREN from Spain [RD16/0009/0016]
- Fundacion Renal Inigo Alvarez de Toledo'' from Spain
- European Cooperation in Science and Technology/COST action [BM-1203]
- MINECO program of Formacion de Personal Investigador [FPIBES-2013-065986]
- Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias [PI14/01374]
- European Regional Development Funds from the European Union
- NIH [R35HL135820]
- Foundation Leducq Transatlantic Network of Excellence in Cardiovascular Research
- AHA Established Investigator Award [16EIA27550004]
Significance: MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors. Critical Issues: The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed. Future Directions: We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles.
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