期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 62, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00110-18
关键词
carbapenem resistance; plasmids; NDM; Escherichia coli; carbapenemase; carbapenems
资金
- National Natural Science Foundation of China [81222025, 81572030, 81772233, 81661130159]
- Newton Advanced Fellowship, Royal Society, United Kingdom [NA150363]
In a carbapenem-resistant Escherichia coli clinical isolate of sequence type 167, two copies of bla(NDM-5) were found on a 144,225-bp IncF self-transmissible plasmid of the F36:A4:B- type. Both blaNDM-5 genes were located in 11,065-bp regions flanked by two copies of IS26. The two regions were identical in sequence but were present at different locations on the plasmid, suggesting a duplication of the same region. This study highlights the complex genetic contexts of bla(NDM-5).
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