期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 18, 期 3, 页码 394-400出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520617666170522123742
关键词
Silver(I) phosphine complexes; esophageal cancer; apoptosis; drug discovery; cytotoxicity; anticancer activity
资金
- University of Johannesburg
- SASOL
- TESP
- CANSA
- National Research Foundation of South Africa
Background: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)(2)]NO3 (2); [Ag(PPh3)(3)]NO3 (3) and [Ag(PPh3)(4)]NO3 (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph2P(CH2)(2)PPh2)(2)]NO3 (5) and [Ag(Ph2P(CH2)(3)PPh2)(2)]NO3 (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). Results: The majority of the complexes (specifically those containing PPh3) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue (R) assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. Conclusion: These results may have an impact on research related to drug discovery and silver(I) phosphine comple(x)es could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts..
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