期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13
卷 13, 期 -, 页码 379-394出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-051217-111018
关键词
glymphatic; cerebrospinal fluid; perivascular space; aquaporin-4; amyloid-beta; astrocyte
类别
资金
- NIA NIH HHS [RF1 AG057575, R01 AG048769] Funding Source: Medline
- NINDS NIH HHS [R01 NS100366, R01 NS078304] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS078304, R01NS100366] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG048769, RF1AG057575] Funding Source: NIH RePORTER
The central nervous system (CNS) is unique in being the only organ system lacking lymphatic vessels to assist in the removal of interstitial metabolic waste products. Recent work has led to the discovery of the glymphatic system, a glial-dependent perivascular network that subserves a pseudolymphatic function in the brain. Within the glymphatic pathway, cerebrospinal fluid (CSF) enters the brain via periarterial spaces, passes into the interstitium via perivascular astrocytic aquaporin-4, and then drives the perivenous drainage of interstitial fluid (ISF) and its solute. Here, we review the role of the glymphatic pathway in CNS physiology, the factors known to regulate glymphatic flow, and the pathologic processes in which a breakdown of glymphatic CSF-ISF exchange has been implicated in disease initiation and progression. Important areas of future research, including manipulation of glymphatic activity aiming to improve waste clearance and therapeutic agent delivery, are also discussed.
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