期刊
ANNUAL REVIEW OF NUTRITION, VOL 38
卷 38, 期 -, 页码 273-301出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-082117-051644
关键词
intestinal stem cells; calorie restriction; fasting; high-fat diet; cancer
资金
- NATIONAL CANCER INSTITUTE [R01CA034992, R01CA211184] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R00AG045144] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA034992, R01 CA211184] Funding Source: Medline
- NIA NIH HHS [R00 AG045144] Funding Source: Medline
Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases including cancer. Stem cells, the central mediators of tissue regeneration, integrate dietary and energy cues via nutrient-sensing pathways to maintain growth or respond to stress. We discuss emerging data on the effects of diet and nutrient-sensing pathways on intestinal stem cells, as well as their potential application in the development of regenerative and therapeutic interventions.
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