期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 41
卷 41, 期 -, 页码 61-76出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-080317-061853
关键词
myelin plasticity; adaptive myelination; glia; neuroplasticity; neuron-glia interactions
Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function. These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity with broad implications for neurological function. In this article, I consider the contributions of myelin to neural circuit function, the dynamic influences of experience on myelin microstructure, and the role that plasticity of myelin may play in cognition.
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