期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36
卷 36, 期 -, 页码 667-694出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-042617-053309
关键词
RIG-I-like receptors; RLR; DExD/H box helicases; Toll-like receptors; TLR; RNA sensing; antiviral immunity; innate immune signaling
类别
资金
- NIAID NIH HHS [R01 AI118916] Funding Source: Medline
- NIH HHS [P51 OD010425] Funding Source: Medline
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD010425] Funding Source: NIH RePORTER
Pattern recognition receptors (PRRs) survey intra- and extracellular spaces for pathogen-associated molecular patterns (PAMPs) within microbial products of infection. Recognition and binding to cognate PAMP ligand by specific PRRs initiates signaling cascades that culminate in a coordinated intracellular innate immune response designed to control infection. In particular, our immune system has evolved specialized PRRs to discriminate viral nucleic acid from host. These are critical sensors of viral RNA to trigger innate immunity in the vertebrate host. Different families of PRRs of virus infection have been defined and reveal a diversity of PAMP specificity for wide viral pathogen coverage to recognize and extinguish virus infection. In this review, we discuss recent insights in pathogen recognition by the RIG-I-like receptors, related RNA helicases, Toll-like receptors, and other RNA sensor PRRs, to present emerging themes in innate immune signaling during virus infection.
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