期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 47
卷 47, 期 -, 页码 655-673出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-060414-034107
关键词
mitotic spindle; molecular motors; microtubules; kinesin; dynein; active gel theory
类别
The assembly of the mitotic spindle and the subsequent segregation of sister chromatids are based on the self-organized action of microtubule filaments, motor proteins, and other microtubule-associated proteins, which constitute the fundamental force-generating elements in the system. Many of the components in the spindle have been identified, but until recently it remained unclear how their collective behaviors resulted in such a robust bipolar structure. Here, we review the current understanding of the physics of the metaphase spindle that is only now starting to emerge.
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