期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20
卷 20, 期 -, 页码 253-275出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-062117-121215
关键词
platelet; mechanotransduction; mechanosensing; shear; force; substrate stiffness
资金
- NHLBI NIH HHS [R01 HL121264, R01 HL130918, T32 HL116271, U54 HL112309, R01 HL101972] Funding Source: Medline
The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand-receptor interactions governing the recruitment, activation, and aggregation of platelets. The physical biology of each step is distinct in that the recruitment of platelets depends on the mechanosensing of the platelet receptor glycoprotein Ib for the adhesive protein von Willebrand factor, whereas platelet activation and aggregation are responsive to the mechanical forces sensed at adhesive junctions between platelets and at the platelet-matrix interface. Herein we take a biophysical perspective to discuss the current understanding of platelet mechanotransduction as well as the measurement techniques used to quantify the physical biology of platelets in the context of thrombus formation under flow.
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