期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87
卷 87, 期 -, 页码 479-502出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-062917-012550
关键词
DNA-encoded chemical libraries; combinatorial chemistry; drug discovery
资金
- European Research Council [670603] Funding Source: Medline
- Swiss National Science Foundation [163479] Funding Source: Medline
The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology, and the biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification bar codes, allows the construction and screening of combinatorial libraries of unprecedented size, thus facilitating the discovery of ligands to many different protein targets. Fundamentally, one links powers of genetics and chemical synthesis. After the initial description of DNA-encoded chemical libraries in 1992, several experimental embodiments of the technology have been reduced to practice. This review provides a historical account of important milestones in the development of DNA-encoded chemical libraries, a survey of relevant ongoing research activities, and a glimpse into the future.
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