期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87
卷 87, 期 -, 页码 503-531出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-063011-164509
关键词
polyketide synthase; fatty acid synthase; structural biology; enzymology; natural products; directed biosynthesis
资金
- NIGMS NIH HHS [P41 GM103393] Funding Source: Medline
Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid synthases (FASs). The focus of this review is to critically compare the properties of FASs with iterative aromatic PKSs, including type II PKSs and fungal type I nonreducing PKSs whose chemical logic is distinct from that of modular PKSs. This review focuses on structural and enzymological studies that reveal both similarities and striking differences between FASs and aromatic PKSs. The potential application of FAS and aromatic PKS structures for bioengineering future drugs and biofuels is highlighted.
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