期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 15, 期 6, 页码 773-787出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.2015.1036744
关键词
atherosclerosis; cancer diagnostics; cell imaging; disease recognition; infectious diseases; Raman spectroscopy
类别
资金
- Carl Zeiss Stiftung
- Jenaer Biochip Initative 2.0 (JBCI 2.0)
- Federal Ministry of Education and Research (BMBF), Germany [03IPT513Y]
Over the last decade, Raman spectroscopy has gained more and more interest in research as well as in clinical laboratories. As a vibrational spectroscopy technique, it is complementary to the also well-established infrared spectroscopy. Through specific spectral patterns, substances can be identified and molecular changes can be observed with high specificity. Because of a high spatial resolution due to an excitation wavelength in the visible and near-infrared range, Raman spectroscopy combined with microscopy is very powerful for imaging biological samples. Individual cells can be imaged on the subcellular level. In vivo tissue examinations are becoming increasingly important for clinical applications. In this review, we present currently ongoing research in different fields of medical diagnostics involving linear Raman spectroscopy and imaging. We give a wide overview over applications for the detection of atherosclerosis, cancer, inflammatory diseases and pharmacology, with a focus on developments over the past 5 years. Conclusions drawn from Raman spectroscopy are often validated by standard methods, for example, histopathology or PCR. The future potential of Raman spectroscopy and its limitations are discussed in consideration of other non-linear Raman techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据