期刊
RSC ADVANCES
卷 6, 期 43, 页码 36923-36931出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra01441k
关键词
-
资金
- National Natural Science Foundation of China [21073143]
- Ministry of Education of China [Z2009-1-71002, Z2009-1-71006]
- NPU Foundation for Graduate Innovation
Two novel metal complexes 2-3 (metal = Pd-II, Pt-II) have been synthesized by reacting the corresponding tolylterpyridine complexes and the 4-aminonaphthalimide derivative 1. The interactions of the complexes with duplex DNA and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy and fluorescence spectroscopy. The studies reveal that the complexes 2-3 possess high affinity and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Spectroscopic and molecular docking studies suggest that the complexes 2-3 interact with telomeric G-quadruplex DNA mainly through groove binding. The compounds 1-3 are emissive (Phi(em) > 0.22), making it possible to study the localization of 1-3 in A549 using fluorescence microscopy. The complexes 2-3 are mainly localized in nuclei, while 1 is localized in the nuclei and cytoplasmic region after 0.5 h incubation. The complex 3 inhibits A549 cells selectively over non-cancerous NIH3T3 cells, with higher antitumor activity than 1 and cisplatin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据