期刊
ANNALS OF SURGERY
卷 268, 期 3, 页码 513-525出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SLA.0000000000002917
关键词
breast cancer-related lymphedema; extremity lymphedema; lymphatic microsurgery; lymphedema diagnosis; Cheng Lymphedema Grading System; lymphoscintigraphy
类别
资金
- Chang Gung Memorial Hospital
- University of Michigan [CORPG3G0131]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [2 K24-AR053120-06]
Objective: The aim was to validate the new Taiwan Lymphoscintigraphy Staging, correlate it with Cheng Lymphedema Grading (CLG) and evaluate the treatment outcomes of unilateral extremity lymphedema. Background: No consensus has been reached for diagnosis and staging for patients with lymphedema among medical specialties. Methods: We included 285 patients with unilateral extremity lymphedema using lymphoscintigraphy. Lymphoscintigraphy was correlated to clinical symptoms and signs, and classified into normal lymphatic drainage, partial obstruction, and total obstruction. Inter- and intraobserver reliability of Taiwan Lymphoscintigraphy Staging, correlation between Taiwan Lymphoscintigraphy Staging and clinical findings were conducted. Patients were categorized in surgical (n = 154) or nonsurgical (n = 131) groups for outcome evaluation. Results: Lymphoscintigraphy found 11 patients (3.9%) with normal lymphatic drainage, 128 (44.9%) with partial obstruction, and 146 (51.2%) with total obstruction. Taiwan Lymphoscintigraphy Staging showed high interobserver agreement [intraclass correlation coefficient: 0.89 (95% confidence interval, 0.82-0.94)], and significantly correlated to computed tomography volumetric difference (r = 0.66, P < 0.001) and CLG [intraclass correlation coefficient: 0.79 (95% confidence interval 0.72-0.84)]. At a mean follow-up of 31.22.9 months, significant improvement in the circumferential difference (from 23.9%+/- 17.6% to 14.6%+/- 11.1%; P = 0.03) with a mean circumferential reduction rate of 40.4%+/- 4.5% was found in surgical group. At a mean follow-up of 26.6 +/- 8.7 months, the nonsurgical group had increase of mean circumferential difference from 24.0%+/- 17.2% to 25.3%+/- 19.0% (P = 0.09), with a mean circumferential reduction rate was -1.9%+/- 13.0%. Conclusions: The Taiwan Lymphoscintigraphy Staging is a reliable diagnostic tool, correlated with clinical findings and CLG, aiding in the selection of the appropriate treatment to achieve favorable long-term outcomes in unilateral extremity lymphedema.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据