期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 11, 期 12, 页码 1335-1351出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2015.1085306
关键词
alopecia areata; autoimmune inflammation; hair follicles; lymphocytes; pathogenesis; treatment
类别
资金
- North American Hair Research Society (NAHRS)
- Canadian Dermatology Foundation (CDF)
- Canadian Institutes of Health Research [MSH-95328]
- Michael Smith Foundation for Health Research [CI-SCH-00480(06-1)]
Alopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri-and intra-follicular regions, and hair follicle disruption. Both CD4(+) and CD8(+) lymphocytes are abundant in AA lesions; however, CD8(+) cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8(+) cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the self-antigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8(+) cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据