期刊
BIOMEDICAL MATERIALS
卷 11, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1748-6041/11/1/015007
关键词
electrospinning; shape memory polymer; tissue regeneration; polydimethylsiloxane; poly(epsilon-caprolactone)
A porous shape memory scaffold with biomimetic architecture is highly promising for bone tissue engineering applications. In this study, a series of new shape memory polyurethanes consisting of organic poly(epsilon-caprolactone) (PCL) segments and inorganic polydimethylsiloxane (PDMS) segments in different ratios (9:1, 8:2 and 7:3) was synthesised. These PCL-PDMS copolymers were further engineered into porous fibrous scaffolds by electrospinning. With different ratios of PCL: PDMS, the fibers showed various fiber diameters, thermal behaviour and mechanical properties. Even after being processed into fibrous structures, these PCL-PDMS copolymers maintained their shape memory properties, and all the fibers exhibited excellent shape recovery ratios of >90% and shape fixity ratios of >92% after 7 thermo-mechanical cycles. Biological assay results corroborated that the fibrous PCL-PDMS scaffolds were biocompatible by promoting osteoblast proliferation, functionally enhanced biomineralization-relevant alkaline phosphatase expression and mineral deposition. Our study demonstrated that the PCL-PDMS fibers with excellent shape memory properties are promising substrates as bioengineered grafts for bone regeneration.
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