期刊
ANNALS OF NEUROLOGY
卷 83, 期 4, 页码 854-857出版社
WILEY
DOI: 10.1002/ana.25191
关键词
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资金
- Medical Faculty of the University of Heidelberg
- Else-Kroner-Fresenius Foundation
- EFSD/JDRF/Novo Nordisk European Program in Type 1 Diabetes Research
- German Research Council [SFB 1158 TPA3, SFB 1118]
- Marta and Erik Karberg Foundation for Medical Research
Schwannomatosis and neurofibromatosis type 2 are hereditary tumor syndromes, and peripheral neuropathy has been reported in both. We prospectively applied in vivo morphometric measurement of dorsal root ganglia volume in 16 schwannomatosis patients, 14 neurofibromatosis type 2 patients, and 26 healthy controls by magnetic resonance neurography. Compared to healthy controls, dorsal root ganglia hypertrophy was a consistent finding in neurofibromatosis type 2 (L3,+267%; L4,+235%; L5,+241%; S1,+300%; S2,+242%; Bonferroni-adjusted p<0.001) but not in schwannomatosis. Dorsal root ganglia may be a vulnerable site in origination of areflexia and sensory loss and a useful diagnostic marker in neurofibromatosis type 2. Ann Neurol 2018;83:854-857
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