期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 13, 期 5, 页码 605-613出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14787210.2015.1023291
关键词
antibiotics; chronic leg ulcers; chronic wounds; Pseudomonas aeruginosa; Staphylococcus aureus
Chronic leg ulcers affect 1-2% of the general population and are related to increased morbidity and health costs. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria isolated from chronic wounds. They can express virulence factors and surface proteins affecting wound healing. The co-infection of S. aureus and P. aeruginosa is more virulent than single infection. In particular, S. aureus and P. aeruginosa have both intrinsic and acquired antibiotic resistance, making clinical management of infection a real challenge, particularly in patients with comorbidity. Therefore, a correct and prompt diagnosis of chronic wound infection requires a detailed knowledge of skin bacterial flora. This is a necessary prerequisite for tailored pharmacological treatment, improving symptoms, and reducing side effects and antibiotic resistance.
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