期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 19, 期 8, 页码 1011-1015出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2015.1044976
关键词
mechanistic target of rapamycin complex 1; mechanistic target of rapamycin complex 2; sestrin; v-akt murine thymoma viral oncogene homolog
资金
- NIDDK NIH HHS [R01DK09159, R01 DK091592] Funding Source: Medline
Sestrins (Sesn1/2/3) belong to a small protein family that has versatile biological functions. In addition to initially characterized oxidoreductase activity, sestrins also have oxidoreductase-independent functions, including activation of AMP-activated protein kinase, inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) and activation of mTORC2. As these kinases are important for metabolic regulation, sestrins hie a favorable profile as potential therapeutic targets for metabolic diseases such as diabetes. Recent data are in line with such a notion. In this editorial, I have attempted to provide a brief update on the major findings in regard to sestrins in metabolism.
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