期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 64, 期 6, 页码 650-654出版社
PHARMACEUTICAL SOC JAPAN
关键词
preservative; disinfection by-product; metabolic reaction; standard chemical synthesis; aryl hydrocarbon receptor
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [26410195]
- Grants-in-Aid for Scientific Research [26410195] Funding Source: KAKEN
We investigated the kinetics of in vitro transformation of a dichlorinated propyl paraben (2-propyl 3,5-dichloro-4-hydroxybenzoate; Cl(2)pP) by the rat liver S9 fraction and assessed the aryl hydrocarbon receptor (AhR) agonist activity of the metabolite products identified in HPLC and GC/MS analysis and by metabolite syntheses. The results indicated that the chlorination of Cl2PP reduced its degradation rate by approximately 40-fold. Two hydroxylated metabolite products showed AhR agonist activity of up to 39% of that of the parent Cl2PP when assessed in a yeast (YCM3) reporter gene assay. The determination of the metabolic properties of paraben bioaccumulation presented here provides further information on the value of risk assessments of chlorinated parabens as a means to ensure human health and environmental safety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据