期刊
ANGIOGENESIS
卷 21, 期 3, 页码 425-532出版社
SPRINGER
DOI: 10.1007/s10456-018-9613-x
关键词
Angiogenesis; Aortic ring; Endothelial cell migration; Proliferation; Microfluidic; Zebrafish; Chorioallantoic membrane (CAM); Vascular network; Intussusceptive angiogenesis; Retinal vasculature; Corneal angiogenesis; Hindlimb ischemia; Myocardial angiogenesis; Recombinant proteins; Tip cells; Plug assay; Myocardial angiogenesis; Vessel co-option
资金
- Dutch Cancer Society [VU2012-5480, VU2014-7234]
- European Research Council (ERC) Starting Research Grant [EU-ERC680209]
- Advanced Research Grant [EU-ERC269073]
- FWO Postdoctoral Fellowships
- Federal Government Belgium grant [IUAP P7/03]
- Flemish Government
- Research Foundation Flanders (FWO)
- Foundation Leducq Transatlantic Network (ARTEMIS)
- Foundation Against Cancer
- AXA Research Fund
- INSERM
- Association pour la Recherche sur le Cancer (ARC)
- Ligue Nationale du Cancer
- Swiss National Science Foundation [31003A_159824, CRSII3_154499]
- British Heart Foundation
- National Institutes of Health [R01 HL096384, R01 HL27030, R01 AR069038, R01 HL128452, R21 AI123883, R01 CA188404, R01 CA201537]
- MRC [MR/N022556/1] Funding Source: UKRI
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [U54HD090255, ZIAHD008915, ZIAHD001011] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA208205, R01CA188404, P01CA080124, P30CA016042, R35CA197743, R01CA201537] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY017017, R24EY024864] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL136139, R01HL096384, R01HL128168, R01HL119043, R01HL128452, R01HL112626, R01HL127030] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI123883] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR069038] Funding Source: NIH RePORTER
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
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