期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 34, 页码 10923-10927出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805528
关键词
C-H functionalization; diazo transfer; flow chemistry; hollow fiber reactor; rhodium
资金
- NSF under the CCI Center for Selective C-H Functionalization [CHE-1700982]
A scalable flow reactor is demonstrated for enantioselective and regioselective rhodium carbene reactions (cyclopropanation and C-H functionalization) by developing cascade reaction methods employing a microfluidic flow reactor system containing immobilized dirhodium catalysts in conjunction with the flow synthesis of diazo compounds. This allows the utilization of the energetic diazo compounds in a safe manner and the recycling of the dirhodium catalysts multiple times. This approach is amenable to application in a bulk-scale synthesis employing asymmetric C-H functionalization by stacking multiple fibers in one reactor module. The products from this sequential flow-flow reactor are compared with a conventional batch reactor or flow-batch reactor in terms of yield, regioselectivity, and enantioselectivity.
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