期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 6, 页码 1537-1542出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710642
关键词
gels; nanofibers; peptides; phase transitions; self-assembly
资金
- National Natural Science Foundation of China [21522307, 21473208, 91434103]
- Talent Fund of the Recruitment Program of Global Youth Experts
- Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) [QYZDB-SSW-JSC034]
- CAS President's International Fellowship Initiative [2017DE0004, 2017VEA0023]
Secondary structures such as alpha-helix and beta-sheet are the major structural motifs within the three-dimensional geometry of proteins. Therefore, structure transitions from beta-sheet to alpha-helix not only can serve as an effective strategy for the therapy of neurological diseases through the inhibition of -sheet aggregation but also extend the application of alpha-helix fibrils in biomedicine. Herein, we present a charge-induced secondary structure transition of amyloid-derived dipeptide assemblies from beta-sheet to alpha-helix. We unravel that the electrostatic (charge) repulsion between the C-terminal charges of the dipeptide molecules are responsible for the conversion of the secondary structure. This finding provides a new perspective to understanding the secondary structure formation and transformation in the supramolecular organization and life activity.
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