期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 27, 页码 8120-8124出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803480
关键词
chiral resolution; inhibitors; polymers; self-assembly; self-reporting
资金
- National Natural Science Foundation of China [21674002]
- BMBF under the project of the Leibniz Research Cluster [031A360D]
Collection of two optically pure enantiomers in a single crystallization process can significantly increase the chiral separation efficiency but this is difficult to realize. Now a self-reporting strategy is presented for visualizing the crystallization process by a dyed self-assembled inhibitor made from the copolymers with tri(ethylene glycol)-grafting polymethylsiloxane as the main chain and poly(N-6-methacryloyl-L-lysine) as side chains. When applied with seeds together for the fractional crystallization of conglomerates, the inhibitors can label the formation of the secondary crystals and guide the complete separation process of two enantiomers with colorless crystals as the first product and red crystals as the second. This method leads to high optical purity of D/L-AsnH(2)O (99.9% ee for D-crystals and 99.5% for L-crystals) in a single crystallization process. It requires a small amount of additives and shows excellent recyclability.
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