期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 37, 页码 12167-12170出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806659
关键词
heterocycles; photocatalysis; radical reactions; rearrangement
资金
- Eli Lilly and Company
The photocatalytic preparation of aminoalkylated heteroarenes from haloalkylamides via a 1,4-aryl migration from nitrogen to carbon, conceptually analogous to a radical Smiles rearrangement, is reported. This method enables the substitution of amino groups in heteroaromatic compounds with aminoalkyl motifs under mild, iridium(III)-mediated photoredox conditions. It provides rapid access to thienoazepinone, a pharmacophore present in multiple drug candidates for potential treatment of different conditions, including inflammation and psychotic disorders.
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