期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 26, 页码 7654-7658出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803558
关键词
allylation; asymmetric catalysis; iridium; total synthesis; trimethyl orthoacetate
资金
- ETH Zurich
- Swiss National Science Foundation [200020_152898]
- Swiss National Science Foundation (SNF) [200020_152898] Funding Source: Swiss National Science Foundation (SNF)
Trimethyl orthoacetate and ethylene glycol mono-vinyl ether are employed in iridium-catalyzed enantioselective allylation reactions. The method documented enables their convenient use as surrogates for silyl ketene acetals and silyl enol ethers to prepare gamma,delta-kunsaturated esters and protected aldehydes with excellent enantioselectivity. The utility of this novel method has been demonstrated by its implementation in a formal enantioselective synthesis of the meroterpenoid (+)-conicol.
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