Palladium-Catalyzed Asymmetric C(sp(3))-H Allylation of 2-Alkylpyridines

The palladium-catalyzed asymmetric side-chain C(alpha)-allylation of 2-alkylpyridines, without using an external base, was developed. The high linear selectivities and enantioselectivities were achieved using new chiral diamidophosphite monodentate ligands. Given that the reaction conditions do not require an external base, this catalyst system enabled chemoselective C(alpha)-allylation of 2-alkylpyridines containing alpha-carbonyl C-H bonds, which are more acidic than alpha-pyridyl C-H bonds.