期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 31, 页码 9875-9879出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806159
关键词
hydrogen gas; magnesium; medical gas; osteoarthritis; tissue inflammation
资金
- Ministry of Science and Technology of the Republic of China, Taiwan [MOST-106-2119-M-007-007]
Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H-2) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H-2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H-2 at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an insitu depot that can evolve gaseous H-2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes.
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