期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 22, 页码 6667-6671出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201802710
关键词
alkyl radicals; conjugate addition; desulfuration; photoredox catalysis; radical reactions
资金
- National Natural Science Foundation of China [21732005, 21702140]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2018ZX09711003-015]
- Fundamental Research Funds for the Central Universities (Postdoctoral Foundation of Sichuan University) [2018SCU12027]
Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible-light photoredox catalysis. A process that involves the generation of N-centered radicals from sulfinamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional-group tolerance.
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