期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 52, 页码 16946-16958出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806470
关键词
bioelectronics; biomaterial; flexible electronics; medical device; polymer
资金
- National Institutes of Health [R21NS095250]
- Defense Advanced Research Projects Agency [D14AP00040]
- National Science Foundation [DMR1542196]
Ingestible biomedical devices that diagnose, prevent, or treat diseases has been a dream of engineers and clinicians for decades. The increasing apparent importance of gut health on overall well-being and the prevalence of many gastrointestinal diseases have renewed focus on this emerging class of medical devices. Several prominent examples of commercially successful ingestible medical devices exist. However, many technical challenges remain before ingestible medical devices can achieve their full clinical potential. This Minireview summarizes recent discoveries in this interdisciplinary topic including novel materials, advanced materials processing techniques, and select examples of integrated ingestible electromechanical systems. After a brief historical perspective, these topics will be reviewed with a dedicated focus on advanced functional materials and fabrication strategies in the context of clinical translation and potential regulatory considerations. Future perspectives, challenges, and opportunities related to ingestible medical devices will also be summarized.
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