期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 33, 页码 10732-10736出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803384
关键词
alpha-diazoketones; beta-heteroaryl ketone; C-H activation; manganese; relay catalysis
资金
- Alexander von Humboldt Foundation
- Deutsche Forschungsgemeinschaft (Leibniz Award)
An unprecedented Mn-I/Ag-I-relay-catalyzed C(sp(2))-H/C(sp(3))-H coupling of (vinyl)arenes with alpha-diazoketones is reported, wherein the diazo group was exploited as a traceless auxiliary for control of regioselectivity. Challenging beta-(hetero)aryl/alkenyl ketones were obtained through this operationally simple approach. The cascade process merges denitrogenation, carbene rearrangement, C-H activation, and hydroarylation/hydroalkenylation. The robustness of this method was demonstrated at preparative scale and applied to late-stage diversification of natural products.
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