期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 14, 页码 3626-3630出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712528
关键词
colon cancer; fluorescence; invivo imaging; nanoprobes; second near-infrared window
资金
- National Science Foundation of China [21672062, 21421004, 11675251, 21390414]
- Programme of Introducing Talents of Discipline to Universities [B16017]
- National Key R&D Program of China [2016YFA0201200, 2016YFA0400900]
- CAS [QYZDJ-SSW-SLH031]
Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300nm. By using this activatable and target specific probe for deep-tissue imaging of H2S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.
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