期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 14, 页码 3763-3766出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201712395
关键词
asymmetric catalysis; chirality; organocatalysis; phase-transfer catalysis; small ring systems
资金
- Hong Kong RGC [16302617, 16311616, ECS605812, 16304115]
- Shenzhen STIC [JCYJ20160229205441091]
Counterion-induced stereocontrol is a powerful tool in organic synthesis. However, such enantiocontrol on tetrahedral ammonium cations remains challenging. Described here is the first example of using chiral anion phase-transfer catalysis to achieve intermolecular ring-opening of azetidiniums with excellent enantioselectivity (up to 97% ee). Precise control over the formation and reaction of the chiral ion pair as well as inhibition of the background reaction by the biphasic system is key to the success of the reaction.
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