期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 7, 页码 1968-1972出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710698
关键词
aryl halides; hydroxylation; nickel catalysis; phenols; photoredox catalysis
资金
- National Natural Science Foundation of China [21372148]
- Program for Changjiang Scholars
- 111 Project [B14041]
- EPSRC [EP/K039687/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K039687/1] Funding Source: researchfish
A highly effective hydroxylation reaction of aryl halides with water under synergistic organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols originates from water, following deprotonation facilitated by an intramolecular base group on the ligand. Significantly, aryl bromides as well as less reactive aryl chlorides served as effective substrates to afford phenols with a wide range of functional groups. Without the need for a strong inorganic base or an expensive noble-metal catalyst, this process can be applied to the efficient preparation of diverse phenols and enables the hydroxylation of multifunctional pharmaceutically relevant aryl halides.
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