期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 18, 页码 4995-4999出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800667
关键词
cyclization; nitrogen heterocycles; radical; samarium; urea
资金
- EPSRC
- Leverhulme Trust
- University of Manchester
- EPSRC [EP/L00125X/1, EP/P001386/1] Funding Source: UKRI
Radical anions generated from urea carbonyls by reductive electron transfer are exploited in carbon-carbon bond formation. New radical cyclizations of urea radical anions deliver complex nitrogen heterocycles and, depending upon the proton source used in the reactions, a chemoselective switch between reaction pathways can deliver two heterobicyclic scaffolds. A computational study has been used to investigate the selectivity of the urea radical processes. Furthermore, radical cyclization cascades involving urea radical anions deliver unusual spirocyclic aminal architectures.
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