期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 23, 页码 6892-6895出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804054
关键词
DNA nanostructures; DNA nanotechnology; metal-ion-free; pH; self-assembly
资金
- National Natural Science Foundation of China [21605033, 21273214, 21425521, 21521001]
- Fundamental Research Funds for the Central Universities [JZ2016HGPA0734]
- National Key Research and Development Program of China [2016YFA0201300]
- Office of Naval Research [N00014-15-1-2707]
- National Science Foundation [CMMI-1437301]
- Hefei University of Technology
- Directorate For Engineering [1437301] Funding Source: National Science Foundation
pH-responsiveness has been widely pursued in dynamic DNA nanotechnology, owing to its potential in biosensing, controlled release, and nanomachinery. pH-triggering systems mostly depend on specific designs of DNA sequences. However, sequence-independent regulation could provide a more general tool to achieve pH-responsive DNA assembly, which has yet to be developed. Herein, we propose a mechanism for dynamic DNA assembly by utilizing ethylenediamine (EN) as a reversibly chargeable (via protonation) molecule to overcome electrostatic repulsions. This strategy provides a universal pH-responsivity for DNA assembly since the regulation originates from externally co-existing EN rather than specific DNA sequences. Furthermore, it endows structural DNA nanotechnology with the benefits of a metal-ionfree environment including nuclease resistance. The concept could in principle be expanded to other organic molecules which may bring unique controls to dynamic DNA assembly.
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