期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 19, 页码 5492-5496出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201801085
关键词
alkynes; copper catalysis; cross-coupling; photochemistry
资金
- NSF [1254636]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1254636] Funding Source: National Science Foundation
We have developed a photoinduced copper-catalyzed alkylation of terminal alkynes with primary, secondary, or tertiary alkyl iodides as electrophiles. The reaction has a broad substrate scope and can be successfully performed in the presence of ester, nitrile, aryl halide, ketone, sulfonamide, epoxide, alcohol, and amide functional groups. The alkylation is promoted by blue light (approximate to 450nm) and proceeds at room temperature in the absence of any additional metal catalysts. The use of a terpyridine ligand is essential for the success of the reaction and is shown to prevent photoinduced copper-catalyzed polymerization of the starting materials.
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