期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 31, 页码 9885-9890出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806551
关键词
nanodots; photodynamic therapy; phthalocyanine; reactive oxygen species; typeI photoreactions
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2012R1A3A2048814]
- National Natural Science Foundation of China [21473033, U1705282]
- National Research Foundation of Korea [2012R1A3A2048814] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via typeI photoreactions (i.e., not by O-1(2) generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the typeI mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications.
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