期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 31, 页码 9744-9748出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804838
关键词
carbon dioxide; carbon-11; carbon-14; heterocycles; isotopic labeling
资金
- Horizon 2020 research and innovation program of the European Union under Marie Sklodowska-Curie grant [675071]
- CEA (program DRF Impulsion)
A robust, click-chemistry-inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable for all carbon isotopes (C-11, C-13, C-14), is based on the direct functionalization of carbon dioxide: the universal building block for carbon radiolabeling. The strategy is operationally simple and reproducible in different radiochemistry centers, exhibits remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity as compared to previously reported systems. With this procedure, a variety of pharmaceuticals and an unprotected peptide were labeled with high radiochemical efficiency.
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