期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 34, 页码 11040-11044出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806527
关键词
asymmetric catalysis; atropisomer; axial chirality; C-H activation; palladium
资金
- Swiss National Science Foundation [175507]
- EPFL Fellows - Marie Sklodowska-Curie, Horizon 2020 program [665667]
Atropo-enantioselective C-H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo-enantioselective palladium(0)-catalyzed methodology that forges the axis of chirality during the C-H functionalization process, enabling the synthesis of axially chiral dibenzazepinones. Computational investigations support experimentally determined racemization barriers, while also indicating C-H functionalization proceeds by an enantio-determining CMD to yield configurationally stable eight-membered palladacycles.
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