期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 24, 页码 7161-7165出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803865
关键词
boronic acid; cooperative catalysis; cross-coupling; palladium; multicomponent reaction
资金
- National Key Research and Development Program of China [2016YFB0101203]
- National 1000-Youth Talents Plan
- Innovation Team Program of Wuhan University [2042017kf0232]
- Wuhan University
Reported is a novel palladium(II)-initiated Catellani-type reaction that utilizes widely accessible aryl boronic acids as the substrates instead of aryl halides, thereby greatly expanding the existing scope of this powerful transformation. This borono-Catellani reaction was promoted by cooperative catalysis between Pd(OAc)(2) and the inexpensive 5-norbornene-2-carbonitrile. Practicality is the striking feature of the reaction: it is run open to air at ambient temperature and no phosphine ligand is needed. This mild, chemoselective, and scalable protocol is compatible with a large range of readily available functionalized aryl boronic acids and bromides, as well as terminating olefins (50 examples, 39-97% yields). Moreover, the orthogonal reactivity between the borono-Catellani and classical Catellani reaction was demonstrated. This work is expected to open new avenues for developing novel Catellani-type reactions.
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